Innate immune system worsens situation in severe COVID-19

Innate immune system worsens situation in severe COVID-19

Peer review / observational study / people

In patients with severe COVID-19, the innate immune system overreacts. This overreaction can lead to the formation of blood clots (thrombi) and deterioration of oxygen saturation which affects patients. This is shown by a study from Uppsala University published in the journal Frontiers in Immunology.

Blood contains many proteins that are the body’s main barrier, recognizing and destroying microorganisms, including SARS-CoV-2 (the virus that causes COVID-19). These proteins are part of the innate intravascular immune system (IIIS), which is made up of certain white blood cells, platelets, and what are called cascading blood systems.

Only 5 percent of current animal species have an immune system that includes T cells and B cells, while the rest depend solely on the natural immune system, which largely consists of IIIS. With its innate ability to recognize and remove foreign substances and particles, such as microorganisms and damaged cells, IIIS acts as a waste disposal system.

In the present study, in 2020, researchers studied 66 hospitalized patients with severe COVID-19 who …

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