Scientists from the University of Surrey have found that synthetic DNA, known as Hachimoji DNA, may have a higher chance of mutations compared to regular DNA. Using density functional theory, the team calculated the speed of proton transfer and how it is affected by temperature, discovering that certain pairs of bases in Hachimoji DNA allow protons to move 30% faster than in regular DNA. Hachimoji DNA is a synthetic form of DNA that is not yet found in natural life, and expands the genetic code beyond the usual four letters (A, T, C, G) to incorporate four additional building blocks (Z, P, S, B).
this article on Technology Networks, synthetic DNA could pave the way for transformative possibilities in medicine and biotechnology. Scientists are exploring the potential of synthetic DNA to engineer fresh genes or enhance existing ones. Synthetic DNA could also sustain Darwinian evolution, leading to exciting advancements in the understanding of genetic systems.
In a unique study, quantum biologists from the University of Surrey investigated how protons move in Hachimoji DNA, a synthetic form of DNA not yet found in natural life. Using a method called density functional theory, the team calculated the speed of proton transfer and how it’s affected by temperature. They found that proton transfer happens more easily in Hachimoji DNA compared to regular DNA. Specifically, certain pairs of bases in Hachimoji DNA allow protons to move 30% faster than in regular DNA. This suggests that Hachimoji DNA might have a higher chance of mutations compared to normal DNA.
Dr Louie Slocombe, lead researcher on the project at the University of Surrey, commented: “The exploration of Hachimoji DNA and its distinctive properties presents exciting prospects for synthetic biology and genetic research. Our study provides invaluable insights into the dynamics of proton transfer within Hachimoji DNA, shedding light on its potential implications for mutation rates. This knowledge has the potential to guide future advancements in DNA engineering and expand our comprehension of genetic systems here on our planet and beyond.”
Hachimoji DNA is synthetic DNA created in a laboratory that expands the genetic code beyond the usual four letters (A, T, C, G). It incorporates four additional building blocks (Z, P, S, B), allowing for more diverse possibilities in genetic information and, crucially, opening up new avenues in genetic research, synthetic biology, and nanotechnology.
The potential of Hachimoji DNA goes beyond genetic research and synthetic biology. As seen on , Hachimoji DNA could help create new biofuels, which could have a significant impact on reducing greenhouse gas emissions. The study’s lead author, Dr. Hyo-Joong Kim, said: “Our findings suggest that Hachimoji DNA could be used to create new biofuels. We believe that this could be a game-changer in the fight against climate change.”
With all of this in mind, the potential of synthetic DNA, particularly Hachimoji DNA, is immense. The study from the University of Surrey sheds light on the dynamics of proton transfer within Hachimoji DNA, providing invaluable insights into its potential implications for mutation rates. The possibilities of Hachimoji DNA go beyond genetic research and synthetic biology, paving the way for exciting advancements in the fight against climate change.