MIT Team Improving Gene Therapies Wins Sloan Health Care Award | MIT News

MIT Team Improving Gene Therapies Wins Sloan Health Care Award |  MIT News

The MIT Kano Therapeutics team on Thursday won the 2021 Sloan Healthcare Innovations Award with its novel approach to single-stranded DNA (ssDNA) production. Technology could make gene therapies safer, more personalized and cheaper.

Most gene therapy uses double stranded DNA, which can miss its target in the body and produce unwanted side effects. Single-stranded DNA has the potential to more precisely delivering genetic material to cells, but manufacturing ssDNA is currently expensive and inflexible.

Kano uses novel approach to produce ss DNA more convenient for applications such as engineering immune cells to fight disease and modifying genomes with CRISPR.

“The sustainable biofabrication of long single-stranded DNA can open doors to gene and cell therapies that we currently only dream of,” says Floris Engelhardt, member of the Kano team, who is currently…

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