Wednesday, October 20, 2021

Multisystem failure linked to frailty requires multisystem intervention

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IMAGE: The diagnosis of frailty is based on three or more five key clinical signs and symptoms: weakness, slow walking speed, low level of physical activity, fatigue or exhaustion, and… involuntary eyesight more

Credit: Jennifer Fairman

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Doctors view frailty as a deregulation between several systems in the body that make it less resilient and unable to fully recover from a physical challenge such as injury or illness. “Defining fragility at the scientific level has, however, been a difficult task”, explains Ravi Varadhan, Ph.D., associate professor of oncology in the division of biostatistics and bioinformatics at the Johns Hopkins Kimmel Cancer Center.

Better understanding physical frailty could potentially help people age more healthy, suggests a Johns Hopkins research team led by Linda Fried, MD, MPH, of Columbia University Mailman School of Public Health (Fried was previously at Johns Hopkins) and Varadhan, in a perspective article published in the issue of january from Aging of nature.

Researchers have developed a system for diagnosing frailty, which is characterized by …

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