Natural product isolated from a sea sponge tested against cancer cells

Natural product isolated from a sea sponge tested against cancer cells

IMAGE: FEFU laboratory for DNA diagnostics, view of the equipment more

Credit: FEFU press office

Scientists at the Federal University of the Far East (FEFU), together with Russian and German colleagues, continue to study anti-tumor compounds synthesized from bioactive molecules isolated from a marine sponge. One of them fights cancer cells resistant to standard chemotherapy and at the same time has an interesting dual mechanism of action. A related article appears in Marine Drugs.

Scientists tested the biological effect of the marine alkaloid 3,10-dibromofascaplysin on various prostate cancer cells, including those resistant to standard docetaxel chemotherapy. The compound was first isolated from the sea sponge Fascaplysinopsis reticulata and then chemically synthesized in FEFU. The substance forces tumor cells to die via a programmed cell death mechanism. This process is called “apoptosis” and is considered to be the most favorable mode of action of anticancer drugs.

“The compound examined, while killing cancer cells, even those resistant to standard chemotherapy, simultaneously activates an enzyme (called & laquokinase”) protecting them …

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