Wednesday, October 20, 2021

Research Identifies Unique Drug Target in Antibiotic-Resistant Bacteria

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Researchers have identified a critical mechanism that allows deadly bacteria to develop resistance to antibiotics.

The findings offer a potential new drug target in the search for new effective antibiotics as we face the growing threat of antimicrobial resistance (AMR) and infections caused by bacterial pathogens.

The study looked at quinolone antibiotics which are used to treat a range of bacterial infections, including tuberculosis (tuberculosis). Quinolones work by inhibiting bacterial enzymes, gyrase and topoisomerase IV, thereby preventing DNA replication and RNA synthesis essential for growth.

They are very effective antimicrobial agents widely used in present day medicine, but bacterial resistance to them and to other treatments is a serious problem.

Previous studies had identified a resistance mechanism caused by the production of repeated pentapeptide proteins (PRP), a family of molecules that also act as inhibitors of DNA gyrase.

One of them, called MfpA, confers quinolone resistance to Mycobacterium tuberculosis, the agent tuberculosis….

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